Olanza 10 Contraindications

Except under special circumstances, this medication should not be used when the following medical problems exists: Hypersensitivity to Olanzapine.
Risk-benefit should be considered when the following medical problems exist: Alzheimer's dementia (dysphagia associated with Olanzapine use may increase risk of aspiration pneumonia; possible increased risk of seizures because of lowered seizure threshold with Alzheimer's dementia); Breast cancer, or history of (prolactin-dependent breast cancers may be exacerbated); Cardiovascular disease, including: Conduction abnormalities or Heart failure or Myocardial infarction or ischemia, or history of, or; Cerebrovascular disease or; Conditions that would predispose to hypotension, including: Dehydration or Hypovolemia (orthostatic hypotension may exacerbated or may exacerbate preexisting cardiovascular or cerebrovascular conditions), (dehydration may predispose medications to increased core body temperature, and antipsychotic medications may disrupt the body's ability to lower core body temperature, thus increasing the risk of heatstroke).
Drug abuse or dependence, history of (patients should be observed closely for signs of misuse or abuse of Olanzapine, as with any new CNS medication); Glaucoma, narrow angle or; Paralytic ileus, history of or; Prostatic hypertrophy, clinically significant (may be exacerbated due to cholinergic antagonism by Olanzapine).
Hepatic function impairment (in premarketing studies, about 1% of patients discontinued Olanzapine treatment due to increased transaminase levels; transaminase levels should be assessed periodically in patients with significant hepatic disease).